Dr. Ghoniem was born in Alexandria, Egypt, and left the country to pursue a fellowship in female urology and neurourology at Brown University in Rhode Island. He went on to complete a urology residency at the University of Michigan. In 1987, Dr. Ghoniem was appointed as Assistant Professor and Chief, Section of Urodynamics and Female Urology at Tulane University in the Department of Urology. Four years later, he was appointed Associate Professor of Urology with a joint appointment in the Department of Gynecology, and then promoted to Professor of Urology and Clinical Professor of Gynecology in 1998.
Dr. Ghoniem founded the section of Voiding Dysfunction, Female Urology, and Pelvic Reconstruction at Cleveland Clinic Florida, where he also served as Chairman of Medical Education.